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In a special edition of the show, in front of an audience at the National Science and Media Museum in Bradford, Adam Rutherford and guests focus on scientific curiosity – its thrills and its dangers.

Professor Matthew Cobb looks back over the last fifty years at the extraordinary development in gene editing. In his book The Genetic Age: Our Perilous Quest to Edit Life he traces the excitement of innovation and progress. But as the full potential of manipulating life is understood, he sounds a warning too.

The science historian Professor Alison Bashford tells the history of modern science and culture through the story of one family – the extraordinary Huxley dynasty. Through four generations the family profoundly shaped how we see ourselves, and pushed the boundaries of knowledge in science, literature and film.

Born in Bradford is an internationally-recognised research programme which aims to find out what keeps families healthy and happy. Professor Deborah Lawlor was born in the city and was one of the many scientists involved in setting up the programme. She explains how this vast ‘city of research’ – with data from more than 700,000 citizens – is being used to improve population health.

Producer: Katy Hickman